Displaying items by tag: preterm infants
Monday, 07 July 2014 11:49

Preterm Birth Breakthrough: Infections

Estimates of preterm birth in Australia suggest one in 12 or approximately 8% of Australian babies is born preterm. The incidence worldwide is even higher, approximately 10%, meaning around 15 million babies are born preterm annually. The estimated cost is very high and Australia spends approximately $500 million per year on their care, whilst the United States spends more than $17 billion.

One of the causes of preterm birth is intrauterine infection or inflammation caused by infection. Experts in the field hypothesise that vaginal microorganisms break the cervical barrier, colonise the fetal membranes, and infect the amniotic cavity. The expectant mother's auto-immune response consistenting of a vigorous inflammatory reaction results in preterm birth.

An incredible breakthrough achieved at the University of Western Australia, King Edward Memorial Hospital, has described the ability of an antibiotic - solithromycin - to potentially cross the placenta and kill infections responsible for many preterm births. Professor Jeffrey Keelan estimated that up to 30% of preterm births could be prevented using this new antibiotic, solithromycin. Most of the benefits would be attributed to saving the very early prems.

The research behind this exciting breakthrough involved measurements in sheep and the crossover from sheep to human placentas is about 50% compared with only 2-4% for older antibiotics and it's 10 to 100 times stronger. Researchers report that the next step is to, confirm that in pregnant women, that the antibiotic crosses the placenta and destroys harmful bacteria. If research grants are successful clinical trials will take place between Western Australia and the United States.

This is a significant finding as currently used antibiotics are largely ineffective at destroying harmful bacteria or are unable to cross the placenta at high enough levels, thereby unable to prevent the preterm birth from occuring.

Published in Industry News
Friday, 25 July 2014 11:21

Creative Preemies

Light ... by Stacie McClinchie



A song has been sung throughout our lands for many generations, the story where a young boy saved our world from a hell-like creature. It tells of the child’s sacrifice to save his land, to help the world prosper once more, for this beast took the greatest treasure we had. It kept it in a chest inside a volcano to the south of our border, and we knew it would take a special kind of person to bring it back.


For years, the peaceful lands of Garduin had been plagued by a menace in the form of a dragon. Even now no one knows where it came from, or why it suddenly attacked anyone who passed through the range near its new home. No one had been brave enough to defeat the beast, for its breath was like the acid rains in the north, its soul as twisted as the dreaded southern forests. Armoured plates covered the massive beast and no amount of metal could break through the tough scales.


This dragon had no name, but whoever could defeat it would have the key to our treasure. No one came to help us. So, a young boy of about nineteen winters took up the challenge. He, too, has no recorded name—but he is our saviour.


Even in his youth he knew facing the dragon in its home was foolish, so he lured it out with offerings of gold. No one thought the dragon would be curious enough to investigate the boy – it, like so many of us, didn’t think that it could be bested by someone who couldn’t even wield a sword properly. He had faith, as the songs say, and the dragon did come.


The battle of insults was long and soon the dragon grew bored—it didn’t expect the boy to have another offering though. We know now that milk is the only liquid that will put a dragon to sleep. Large barrels of it awaited the dragon as it found the place the boy had described once he told the beast of a greater offering of peace.


As the massive beast slumbered, the boy found the dragon’s domain and took the treasure for himself. He didn’t care that the dragon had woken a half-day later to find its treasure stolen—the beast was not as stupid as many had thought. Keeping it a secret no longer bothered the beast, for it had kept it for far too long and many did not appreciate what it has been guarding.


When the boy stopped at the largest and closest town, the one that he was said to have lived in, he gave up the fortune for a chance to live a normal life. He knew he would have to give it up if he was to be free to live his own life, and it did not pain him to do so. Before the ordeal with the dragon, he was merely a stable-hand, with no lands of his own and no hope for a promising future.


Afterwards, he lived a life of luxury.


The treasure that was given to the church that day cannot not be seen by mortal eyes – its existence all depends on secrecy. It is safe now, in the largest church in Garduin. A large orb of light sits inside its box, held aloft by twisting gold marble serpents with crystal eyes; the chest that the dragon had been safeguarding, and this light—this being—is what will secure the future of our world. It is our god’s gift to our people—and what we do with it is up to us. It will either start a war, or help us prosper.


Of course, this is just a legend. We tell them—those who come seeking the treasure taken from the dragon—that there isn’t really a reptilian egg waiting in the catacombs of Garduin. But there is. And only we know of its existence.


Published in Industry News
Wednesday, 14 May 2014 17:23

MRI, Extremely Preterm Birth & IQ

An Australia research group - Victorian Infant Collaborative Study - based in Melbourne investigates both short- and long-term outcomes associated with preterm birth. One of their studies has followed a large cohort, which includes participants from the 4 major children's hospitals in Victoria, 298 preterm survivors and 262 normal birth weight controls. These cohorts have had extensive evaluations of their growth and developments at 2, 5, and 8 years of age and were recently seen for a major follow-up including an extensive cognitive and visual assessment at age 8 years. In addition some 148 extremely preterm survivors and 132 term born controls received a magnetic resonance imaging scan of their brain in order to compare brain volumes from multiple brain tissues and structures as well as to explore the relationships of brain tissue volumes with IQ and basic educational skills.

IQ was assessed using the Wechsler Abbreviated Scale of Intelligence (WASI) and Educational skills were assessed using the Wide Range Achievement Test(WRAT-4).

This research represents the largest regional neuroimaging cohort of adolescents born in the 1990s, which is very important as this cohort represents a group that received "new" medical interventions such as surfactant therapy and antenatal corticosteroids which had greater success in improving survival rates of the smallest and most preterm infants. The long-term outcomes of these survivors have not been well documented until this unique study.

The researchers found that extremely preterm adolescents had smaller brain volumes, lower IQs and poorer educational performance than babies born at term. They also reported that brain volumes of multiple tissues and structures are related to IQ and educational outcomes and concluded that smaller total brain tissue volume is an important contributor to the cognitive and educational underperformance of adolescents born extremely preterm.

The authors of this study suggested that examining brain volume is one of many ways to understand the neurological changes associated with preterm birth and fruther investigations might be able to determine the correlation between other structural and functional information obtained from advanced MRI, which might also provide a more global understanding of changes related to extreme prematurity in adolescence

Published in Industry News
Tuesday, 29 April 2014 09:44

Preemies & Argan Oil

What’s so Good about Argan Oil?

Often called ‘liquid gold’, Argan oil is an organic product produced from an Argan nut coming from Argan tree, which only grows in Southwestern Morocco. Scientific analysis shows it is high in essential fatty acids Omega 6 and 9 to moisturise, maintain hydration and reduce inflammation. Argan oil is also very high in skin repairing antioxidants such as Vitamin E (twice the level of olive oil), carotenes, squalene and phenols. Its anti-oxidant effect makes argan oil the ideal anti-aging product. It restores elasticity and leaves skin feeling plumper and softer.

The active substances called triterpenoids that occur in Argan Oil offer amazing skin protection benefits. These include tissue healing (scars), anti-inflammatory, sun-protective and disinfectant properties.

The oil contains 80% unsaturated fatty acids and is more resistant to oxidation than olive oil. Argan oil also contains 0.8% unsaponifiables (a large group of compounds also known as plant sterols or sterolins). Sterolins improve skin metabolism, reduce inflammation and promote excellent moisture retention. The antioxidants in Argan Oil are generally beneficial for healing skin which is irritated, cracked, damaged, or even burned. It is best used as a preventative for dry or sore skin, but it can also be used to speed up healing. Its properties include reducing inflammation, soothing pain, and increasing healing rate. It absorbs easily and is non-greasy and non-irritating, which makes it a great natural moisturiser.

Because preemies are often so fragile whilst in the NICU our products focus on skincare after preemie baby is medically stable. After preterm babies leave the NICU their skin is often still very dry and flaky and requires ongoing attention to keep it hydrated, soothed, and protected. Working with experts in the area of skincare, we have been able to formulate a range of products that target some specific needs of preemies. Our products are perfect for when baby comes home.

The entire Gentl skincare range for preemies and preemie parents only includes natural substances such as organic argan oil and/or ingredients that have been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel and found to be safe for cosmetic use.

Published in Industry News

The Victorian Brain Infants Studies (VIBeS) began a very important research project in January 2005, which aimed to establish if receiving developmental care at home was more beneficial than the current standard care, the study is known as the VIBeS Plus program.

There are around 3,000 very low birth weight (less than 1500 grams) or very preterm infants (less than 30 weeks gestational age) born each year in Australia. Survival rates for these very preterm infants have improved dramatically in the last few decades to be greater than 85%, however a significant proportion of children experience movement, behavioural or social problems which have life-long consequences. Early intervention programs, such as the VIBeS Plus program may reduce these risks. To date, the success of these programs has not been fully established.

The original VIBeS Plus study was a randomised control trial of a preventative care intervention. There were 120 families who participated and were randomised to either the “intervention group” or “control group”. The intervention designed by the Victorian Infant Brain Studies (VIBeS) team, consisted of 9 visits over the first year of life, conducted by 2 teams comprising a psychologist and a physiotherapist who were specially trained to deliver the intervention program. The intervention aimed to educate the primary caregivers about infant self-regulation and techniques for improving postural stability, coordination, and strength and to support the parents’ mental health and parent infant relationship throughout the first year. Each session lasted ~1.5 to 2.0 hours and was conducted in the family home, with a few exceptions in which the infants were seen in the hospital. Both groups were offered an MRI scan of their infant's brain at term corrected age.

Many of the neurobehavioral impairments described in preterm children persist into adolescence and adulthood. Further, caregivers of very preterm survivors experience high rates of mental health problems. Studies examining the effectiveness of early developmental intervention programs designed to reduce the burden of developmental problems report short-term benefits for infants and their caregivers.

VIBeS Plus previously demonstrated that at 2 years the early preventive care program improved preterm infants’ behavioural outcomes and reduced primary caregivers’ anxiety and depression. The follow-up study conducted at age 4 years showed that home-based preventive care over the first year had selective long-term benefits. There were meaningful differences in the thinking and learning, language and motor scores between treatment groups. Also, children in the intervention group showed less attention problems, such as ADHD, and behavior difficulties as well as increased competence compared with the controls.

Given the important role of parenting on child development, it is possible that the full benefits of this preventive care program will not be observed until later in development. Thus it is vital to determine whether early preventative care programs have long-term benefits beyond early development and preschool years. VIBeS Plus are currently following up this group of preterm children at school-age. Follow-up at school age is ideal for assessing the usefulness of this program, as this is when brain development and social maturation are relatively stable, and when the social demands of the environment (primary school) are also relatively consistent.

Published in Industry News
Tuesday, 17 June 2014 14:59

Preemie Parents Skin

Talking about parent’s skin might seem weird – after all the skin barrier is fully developed and most people already have their own skincare regime. But preemie parents have some unique skincare needs primarily due to the unique environment of the NICU. If you’re a parent of a preemie baby you will be familiar with the humidity of the NICU – designed to prevent temperature instability, dehydration, and electrolyte imbalance caused by the immaturity of preemie skin. You’ll also be acutely aware of the importance of clean, sterilized hands when handling your prem. You no doubt have a ritual when arriving at the hospital that involves thorough hand washing and sanitizing. These two factors in particular often lead to very dehydrated and under-nourished hands. You probably also notice that your face and lips are also dry and sensitive.

You may not be able to abide by your usual skincare routine and your requirements are likely quite different. It is for these reasons we decided to work with skincare experts to formulate products specifically for preemie parent needs.

One of our best active ingredients in Sea Kelp.

What’s so Good about Sea Kelp?


The medicinal benefits of kelp have been renowned for centuries due to its ability to enhance health and beauty. The seawater where kelp grows contains an abundance of vitamins, minerals, trace minerals, proteins and enzymes that have wonderful benefits for the skin.

Sea Kelp Bioferment can be used as a great nutritive active to skincare lotions and moisturizers. Sea Kelp is firming, healing and soothing for any skin type and is a powerful nutritive moisturizer for normal and dry skin as well as having antioxidant properties, also a fantastic plus for the skin.

Sea Kelp can also help keep skin looking firmer and younger as it helps prevent loss of skin elasticity. Research has demonstrated that the iodine in Sea Kelp effectively removes free radicals - chemicals that accelerate ageing - from human blood cells.

If that wasn’t enough Sea Kelp also contains minerals like calcium, fluorine and magnesium that contribute to a more radiant skin tone. It is also rich in Vitamins A, B1, B2, C and E, as well as minerals such as magnesium, selenium and zinc - vitamins and minerals that are essential to regenerating skin cells and tissue.

The Product!


SEA KELP CORAL NICU HAND CREAM - PROTECTION FORMULA A RICH THICK BARRIER CREAM TO PROVIDE MOISTURIZING PROTECTION FOR HANDS DRY AND TIRED FROM LONG DAYS IN THE NICU This exceptional product provides cover when you need extra protection and will help prevent water loss from damaged skin. A careful blend including sea kelp coral helps soften, moisturize, and remove toxins from the skin. Perfect for skin regularly subjected to air-conditioning and hand sanitiser.

Published in Preemiehelp News
Sunday, 01 June 2014 11:40

Stem Cells Could Help Preterm Infants

Premature babies have underdeveloped lungs and often have difficulty breathing by themselves. Respiratory distress syndrome and chronic lung disease are the most common breathing difficulties related to preterm birth.

Difficulty breathing due to underdeveloped lungs is often a common consequence of preterm birth that needs immediate attention. Respiratory distress syndrome, also called hyaline membrane disease (HMD), is the most common lung disorder in preterm infants. Preterm infants do not produce enough of a slippery, protective substance called surfactant, which helps the lungs inflate with air and keeps them from collapsing, when the infant tries to breathe in air, after birth, by themself. Preterm infants with respiratory distress syndrome are treated with exogenous surfactant and has been shown to decrease neonatal mortality in very low birth weight and preterm infants. Where possible steroids are given to mother’s before a preterm delivery to help prevent problems associated with underdeveloped organs and lung immaturity.

Early difficulties with breathing and the need for ventilation can result in chronic lung disease (CLD), also called bronchopulmonary dysplasia (BPD), which is common in babies born preterm. CLD is a disorder that results from inflammation, injury, and scarring of the airways and the alveoli.

New research which has focused on lung problems associated with preterm birth has reported some fascinating findings. Dr. Bernard Thébaud, who is a pediatrician at the Children’s Hospital of Eastern Ontario and The Ottawa Hospital, published a paper in the medical journal Circulation reporting findings that showed that damaged lungs of preterm infants can be safely repaired using stem cells and regenerative medicine. This is the first study to demonstrate the use of vascular progenitor cells (stem cells that make blood vessels) for this purpose.

Research findings so far are based on research conducted on lab animals but the next phase of the study will begin working on opportunities for clinical trials.

These research findings have huge implications for the treatment of lung disease in preterm infants as well as the potential regeneration of other organs and other lung diseases in adult populations. This research is very important, not just for the short-term benefits but also the potential long-term benefits. For example, a lack of oxygen to other parts of the preemie infant’s body can result in other difficulties. For example, lack of oxygen can affect brain and eye development. Respiratory problems are the most common cause of death in preterm infants, although these problems have lessened over time, and they also have a large effect on other health outcomes. That is, they are related to high rates of cognitive (thinking and reasoning), motor skills, educational, and behavioural difficulties.

Research such as this could be a great step in lessening the burden and stress for families of preterm infants who often have to deal with many and varied many challenges.

Published in Industry News
Monday, 31 March 2014 13:52

Preterm Infants: Visual Processing

An Australia research project looking at the long-term outcome of preterm birth on visual processing has found that despite advances in medical care improving the survival rate of high-risk extremely low birth weight and/or extremely preterm infants, visual morbidity is still relatively high compared with controls in late adolescence.

 

Ocular growth and development differ between extremely low birth weight (ELBW, ,1000 g) or extremely preterm (EP, gestational age ,28 weeks) and term children and may have long-term negative consequences for visual function. Visual sensory and perceptual skills are important for a range of functions and everyday activities, such as classroom learning, overall school performance,successful social interaction, and social cognition. Consequently, understanding the nature and frequency of visual deficits in ELBW/EP children is vital to inform adequate and appropriately targeted clinical follow-up and to increase focus on developing avenues for remediation.

The study involved following up 228 extremely preterm survivors born in Victoria in 1991 and 1992 and 166 randomly selected normal birth weight controls. The participants were assessed between the ages of 14 and 20 years of age. Visual acuity, stereopsis, convergence, color perception, and visual perception were assessed and contrasted between groups.

The researchers reported that adolescents born extemely preterm had worse visual acuity, poorer depth perception, and more problems with visual perception. Given the potential importance of visual perceptual skills to more complex tasks and academic achievement, these results have important clinical relevance.

Published in Industry News
Wednesday, 20 August 2014 08:51

Prevention of Preemie Parent Distress

The birth of a preterm infant can cause significant psychological distress for parents and families. In particular it has been consistently reported that the birth and hospitalisation of an unwell baby is associated with high levels of distress and depressive symptoms in the mother of the infant. Most research in this area has focused on the mother of preterm infants but some research groups are now trying to evaluate the emotional affect preterm birth also has on fathers.

Research suggests that 10% of mothers of infants with very low birth weight (VLBW; infants born less than 1,500 g) report severe symptoms of psychological distress in the neonatal period which is five-fold the rate of term mothers, and almost one-third of mothers of VLBW infants have clinically meaningful levels of depression and anxiety.

A research team in the United States have recently evaluated a treatment intervention developed for reducing symptoms of posttraumatic stress, depression, and anxiety in parents of preterm babies.

There were 105 mothers of preterm infants who particpated in the study. The gestational age of preemies ranged from 25 to 34 weeks' gestational age and all were born more than 600grams. The 105 participants were randomly selected to be part of 2 groups; 1)intervention group - these mothers received 6 sessions of intervention which combined trauma-focused treatments, including psychoeducation, cognitive restructuring, progessive muscles relaxation, and development of their trauma narrative. It also included material which targeted infant redefinition - changing the mother's negative perceptions of her baby and the parenting experience; 2)control group - these mothers were described as an active comparison group who received an education session.

The research findings were positive for the intervention group - mothers greater reduction in trauma symptoms and depression, both groups reported less anxiety, and mothers who experienced higher NICU stress before the intervention benefited more from the intervention than mothers who reported low NICU stress.

The researchers concluded that, "This short, highly manualized intervention for mothers of preterm infants reduced symptoms of trauma and depression. The intervention is feasible, can be delivered with fidelity, and has high ratings of maternal satisfaction. Given that improvements in mothers’ distress may lead to improved infant outcomes, this intervention has the potential for a high public health impact.

Research such as this could be a great step in lessening the burden and stress for families of preterm infants who often have to deal with many and varied challenges.

Published in Industry News

AlbertEinstein_iconOne of the greatest minds in history, Albert Einstein was born preterm.

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Preemie, Premmie, or Prem?

Most babies spend between 38 and 42 weeks in their mother’s uterus. So, technically a preterm birth, preemie, premmie, or prem, is an infant who is born less than 37 completed gestational weeks. 


Read More: Defining Preterm birth


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New Release - Preemie Development

All in one easy to read eguide

‘The complete preemie guide to: ‘Preemie development’ is the must have guide to the NICU for new preemie parents.

With an easy-to-read layout this comprehensive guide is over 130 pages of important information about the NICU and your preemie.

Using Adobe’s .pdf format makes the guide usable across a wide range of platforms from ipad to PC, smartphone to macbook.

Packed with extra features like progress charts, NICU checklists and plenty of others. ‘The preemie guide’ is a must for any new parents.


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